Identification of proximal sequence element nucleotides contributing to the differential expression of variant U4 small nuclear RNA genes.

doi:10.1074/jbc.270.46.27629

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Article

Identification of proximal sequence element nucleotides contributing to the differential expression of variant U4 small nuclear RNA genes.

The Journal of biological chemistry - 17 Nov 1995

Bhathal H S, Zamrod Z, Tobaru T, Stumph W E

Abstract excerpt

The two U4 genes in the chicken genome code for distinct sequence variants of U4 small nuclear RNA that are differentially expressed during development. Whereas U4B RNA is constitutively expressed, U4X RNA is specifically down-regulated relative to U4B in a tissue-specific manner during development. To investigate mechanisms controlling the differential expression of the U4B and U4X genes, chimeric U4 genes were...

Topics

Animals
Base Sequence
Cell Line
Chickens
Chimera
Chlorocebus aethiops
DNA Primers
Enhancer Elements, Genetic
Female
Gene Expression
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome

Kinetics

Molecular Sequence Data

Mutagenesis, Site-Directed

Oocytes

Point Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7499227
DOI: 10.1074/jbc.270.46.27629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7499227-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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