Article

Minor spliceosome disruption causes limb growth defects without altering patterning

2020-03-18

Abstract excerpt

Disruption of the minor spliceosome causes primordial dwarfism in microcephalic osteodysplastic primordial dwarfism type 1. Similarly, primordial dwarfism in domesticated animals is linked to positive selection in minor spliceosome components. Despite the importance of minor intron splicing in limb size regulation, its role in limb development remains unexplored. Here we show that loss of U11 small nuclear RNA, an...

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Literature Corpus work: 26ef685e-7248-5c6c-a1c1-3337b0bc2704
DOI: 10.1101/2020.03.16.994384

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