Branchpoint and polypyrimidine tract mutations mediating the loss and partial recovery of the Moloney murine sarcoma virus MuSVts110 thermosensitive splicing phenotype.

doi:10.1128/JVI.69.12.7724-7733.1995

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Article

Branchpoint and polypyrimidine tract mutations mediating the loss and partial recovery of the Moloney murine sarcoma virus MuSVts110 thermosensitive splicing phenotype.

Journal of virology - 1 Dec 1995

Touchman J W, D'Souza I, Heckman C A, Zhou R, Biggart N W, Murphy E C

Abstract excerpt

Balanced splicing of retroviral RNAs is mediated by weak signals at the 3' splice site (ss) acting in concert with other cis elements. Moloney murine sarcoma virus MuSVts110 shows a similar balance between unspliced and spliced RNAs, differing only in that the splicing of its RNA is, in addition, growth temperature sensitive. We have generated N-nitroso-N-methylurea (NMU)-treated MuSVts110 revertants in which...

Topics

Amino Acid Sequence
Animals
Base Composition
Base Sequence
Cattle
Cell Line
Consensus Sequence
DNA Primers
DNA, Viral
Hot Temperature
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylnitrosourea

Molecular Sequence Data

Moloney murine sarcoma virus

Mutagenesis

Phenotype

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Source

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Identifiers

PMID: 7494282
DOI: 10.1128/JVI.69.12.7724-7733.1995
PMCID: PMC189714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7494282-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Branchpoint and polypyrimidine tract mutations mediating the loss and partial recovery of the Moloney murine sarcoma virus MuSVts110 thermosensitive splicing phenotype.PMID 7494282Read ↗

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