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Article

Replication of minute virus of mice DNA is critically dependent on accumulated levels of NS2.

Journal of virology - 1 Oct 2005

Choi Eun-Young, Newman Ann E, Burger Lisa, Pintel David

Abstract excerpt

Following transfection of murine fibroblasts, the lymphotropic strain of minute virus of mice (MVMi) does not efficiently produce progeny single-strand DNA (ssDNA). However, changing a single nucleotide in the MVMi 3' splice site to that found in the fibrotropic strain MVMp enabled full DNA replication and production of ssDNA. This change enhanced excision of the large intron and the production of NS2, likely by...

Topics

Animals
Cell Line
DNA Replication
DNA, Single-Stranded
DNA, Viral
Fibroblasts
Introns
Mice
Minute Virus of Mice
Mutation
RNA Splice Sites
RNA, Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Viral Nonstructural Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 16160164
DOI: 10.1128/JVI.79.19.12375-12381.2005
PMCID: PMC1211553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Replication of minute virus of mice DNA is critically dependent on accumulated levels of NS2.PMID 16160164Read ↗

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Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.Semantic proximity Read ↗

Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice.Semantic proximity Read ↗

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