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Exploring the potential role of GyrA inhibiting quinoline analog: an in silico study

1 Jul 2025

Abstract excerpt

Fluoroquinolone-resistant Pseudomonas aeruginosa poses a significant global health concern, particularly in healthcare settings. This opportunistic pathogen has developed resistance against multiple classes of antibiotics, rendering infections challenging to treat. The present study focused on identifying quinoline analogs as potential inhibitors of gyrA in fluoroquinolone-resistant P. aeruginosa. Utilizing...

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PMID: 40594094
DOI: 10.1038/s41598-025-04409-2

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