Article
Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV.
The Journal of antimicrobial chemotherapy - 1 Feb 1997
Deguchi T, Yasuda M, Nakano M, Kanematsu E, Ozeki S, Ishihara S, Saito I, Kawada Y
Abstract excerpt
The in-vitro antimicrobial activity of DU-6859a, a new fluoroquinolone, was tested against 55 clinical isolates of Neisseria gonorrhoeae. The MIC of DU-6859a inhibiting 90% (MIC90) of the isolates with genetic alterations of both the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV was 0.125 mg/L. The MIC90 for isolates with alterations of GyrA alone or without alterations of GyrA or ParC was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.