Article
Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 1995
Luo X, Ikeda Y, Schlosser D A, Parker K L
Abstract excerpt
Targeted disruption of the mouse Ftz-F1 gene, which encodes the orphan nuclear receptors steroidogenic factor 1 (SF-1) and embryonal long terminal repeat-binding protein (ELP), established that this gene is essential for development of the primary steroidogenic tissues and for male sexual differentiation. Associated with these dramatic developmental abnormalities, all Ftz-F1-disrupted mice died in the immediate...
Topics
- Adrenal Cortex Hormones
- Adrenal Glands
- Animals
- DNA-Binding Proteins
- Female
- Fushi Tarazu Transcription Factors
- Genitalia, Female
- Homeodomain Proteins
- Male
- Methionine
- Mice