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Article

Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.

The Journal of cell biology - 1 Nov 1995

Lencer W I, Constable C, Moe S, Jobling M G, Webb H M, Ruston S, Madara J L, Hirst T R, Holmes R K

Abstract excerpt

Vibrio cholerae and Escherichia coli heat labile toxins (CT and LT) elicit a secretory response from intestinal epithelia by binding apical receptors (ganglioside GM1) and subsequently activating basolateral effectors (adenylate cyclase). We have recently proposed that signal transduction in polarized cells may require transcytosis of toxin-containing membranes (Lencer, W. I., G. Strohmeier, S. Moe, S. L....

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Identifiers

PMID: 7490296
DOI: 10.1083/jcb.131.4.951
PMCID: PMC2200010

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