Article
Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.
The Journal of cell biology - 1 Nov 1995
Lencer W I, Constable C, Moe S, Jobling M G, Webb H M, Ruston S, Madara J L, Hirst T R, Holmes R K
Abstract excerpt
Vibrio cholerae and Escherichia coli heat labile toxins (CT and LT) elicit a secretory response from intestinal epithelia by binding apical receptors (ganglioside GM1) and subsequently activating basolateral effectors (adenylate cyclase). We have recently proposed that signal transduction in pola...
Topics
- Amino Acid Sequence
- Bacterial Toxins
- Base Sequence
- Cell Compartmentation
- Cell Line
- Cell Polarity
- Cholera Toxin
- Endocytosis
- Enterotoxins
- Epithelial Cells
- Epithelium
- Escherichia coli
- Escherichia coli Proteins
- Humans