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Article

Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat-labile enterotoxin.

Molecular microbiology - 1 May 1995

Cieplak W, Messer R J, Konkel M E, Grant C C

Abstract excerpt

Recent experimental evidence indicates that Escherichia coli heat-labile enterotoxin and the closely related cholera toxin gain access to intracellular target substrates through a brefeldin A-sensitive pathway that may involve retrograde transport through the Golgi-endoplasmic reticulum network. The A subunits of both toxins possess a carboxy-terminal tetrapeptide sequence (KDEL in cholera toxin and RDEL in the...

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PMID: 7476173
DOI: 10.1111/j.1365-2958.1995.tb02440.x

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