Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat-labile enterotoxin.

doi:10.1111/j.1365-2958.1995.tb02440.x

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Article

Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat-labile enterotoxin.

Molecular microbiology - 1 May 1995

Cieplak W, Messer R J, Konkel M E, Grant C C

Abstract excerpt

Recent experimental evidence indicates that Escherichia coli heat-labile enterotoxin and the closely related cholera toxin gain access to intracellular target substrates through a brefeldin A-sensitive pathway that may involve retrograde transport through the Golgi-endoplasmic reticulum network. The A subunits of both toxins possess a carboxy-terminal tetrapeptide sequence (KDEL in cholera toxin and RDEL in the...

Topics

Amino Acid Sequence
Animals
Anti-Bacterial Agents
Bacterial Toxins
Base Sequence
Brefeldin A
CHO Cells
Cell Line
Cricetinae
Cyclic AMP
Cyclopentanes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA, Bacterial

Endoplasmic Reticulum

Enterotoxins

Escherichia coli

Escherichia coli Proteins

Golgi Apparatus

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7476173
DOI: 10.1111/j.1365-2958.1995.tb02440.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7476173-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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