Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Carcinogenic effects in a phenylketonuria mouse model.

PloS one - 1 Jan 2009

Sidell Neil, Hao Lijuan, Pasquali Marzia, McDonald J David

Abstract excerpt

Phenylketonuria (PKU) is a metabolic disorder caused by impaired phenylalanine hydroxylase (PAH). This condition results in hyperphenylalaninemia and elevated levels of abnormal phenylalanine metabolites, among which is phenylacetic acid/phenylacetate (PA). In recent years, PA and its analogs were found to have anticancer activity against a variety of malignancies suggesting the possibility that PKU may offer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Anticarcinogenic Agents
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryl Hydrocarbon Hydroxylases

Share to Carcinogens

Share to Cytochrome P-450 CYP1B1

Share to Phenylacetates

Share to Phenylketonurias

Source

Open in PubMed Open full text

Identifiers

PMID: 19172175
DOI: 10.1371/journal.pone.0004292
PMCID: PMC2625399

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Carcinogenic effects in a phenylketonuria mouse model.PMID 19172175Read ↗

Characterization of the mouse phenylalanine hydroxylase mutation Pah(enu3).Semantic proximity Read ↗

The PKU mouse project: its history, potential and implications.Semantic proximity Read ↗

The use of N-ethyl-N-nitrosourea to produce mouse models for human phenylketonuria and hyperphenylalaninemia.Semantic proximity Read ↗

Behavioral Phenotyping of the Pahenu2 Mouse Model for Phenylketonuria-A Scoping Review and Future Perspectives.Semantic proximity Read ↗

Characterization of mutations at the mouse phenylalanine hydroxylase locus.Semantic proximity Read ↗

Breeding the phenylketonuria mouse: novel dietary regimen enables breeding of female C57BL/6J mice homozygous for the <i> Pah <sup>enu2</sup> </i> mutation without fosteringSemantic proximity Read ↗

Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase.Semantic proximity Read ↗

A heteroallelic mutant mouse model: A new orthologue for human hyperphenylalaninemia.Semantic proximity Read ↗

Metabolic basis of sexual dimorphism in PKU mice after genome-targeted PAH gene therapy.Semantic proximity Read ↗

Pathologic and immunohistochemical findings in hypothalamic and mesencephalic regions in the pah(enu2) mouse model for phenylketonuria.Semantic proximity Read ↗

Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin.Semantic proximity Read ↗

Long-term enzymatic and phenotypic correction in the phenylketonuria mouse model by adeno-associated virus vector-mediated gene transfer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.