Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

doi:10.1073/pnas.93.20.10668

Article

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

1 Oct 1996

Abstract excerpt

Resistance of Lactococcus lactis to cytotoxic compounds shares features with the multidrug resistance phenotype of mammalian tumor cells. Here, we report the gene cloning and functional characterization in Escherichia coli of LmrA, a lactococcal structural and functional homolog of the human multidrug resistance P-glycoprotein MDR1. LmrA is a 590-aa polypeptide that has a putative topology of six alpha-helical...

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