Article
Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity.
The Journal of biological chemistry - 12 Sept 1997
Szabó K, Bakos E, Welker E, Müller M, Goodfellow H R, Higgins C F, Váradi A, Sarkadi B
Abstract excerpt
In the human multidrug transporter (MDR1), three serine residues located in the "linker" region of the protein are targets of in vivo phosphorylation. These three serines, or all eight serines and threonines in the linker, were substituted by alanines (mutants 3A and 8A) or with glutamic acids (m...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Animals
- Baculoviridae
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Enzyme Activation
- Humans
- Mutation
- Phosphorylation