Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine.

doi:10.1016/0166-3542(94)00077-l

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Article

Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine.

Antiviral research - 1 May 1995

Kodama E, Mori S, Shigeta S

Abstract excerpt

We have analyzed mutations in the thymidine kinase (TK) gene of varicella zoster virus (VZV) which showed resistance to 5-iodo-2'-deoxyuridine (IDU) and 5-bromo-2'-deoxyuridine (BrDU). Through sequencing of the TK gene, we found three amino acids were exchanged (41 Asn-->Ser, 266 Cys-->Ile, 288 S...

Topics

Amino Acid Sequence
Amino Acids
Base Sequence
Bromodeoxyuridine
DNA Primers
DNA, Viral
Drug Resistance
Herpesvirus 3, Human
Humans
Idoxuridine
Molecular Sequence Data
Mutation
Point Mutation
Thymidine Kinase

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