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Single Amino Acid Change in DNA Polymerase Is Associated with Foscarnet Resistance in a Varicella‐Zoster Virus Strain Recovered from a Patient with AIDS

1 Nov 1998

Abstract excerpt

The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The emergence of one of the mutations, which includes a change from a glutamic acid to a lysine at...

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PMID: 9852975
DOI: 10.1086/514257

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