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Article

Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet.

Medical microbiology and immunology - 1 Aug 2011

Bleymehl Karoline, Cinatl Jindrich, Schmidt-Chanasit Jonas

Abstract excerpt

The treatment of varicella-zoster virus (VZV) reactivation is based on nucleoside analogues acyclovir (ACV) and bromevinyldeoxyuridine (BVdU) and a phosphonic acid derivative (PFA). Drug-resistant mutants of 3 wild-type (WT) VZV strains were obtained by exposure of human retinal pigment epithelial (hRPE) cells inoculated with cell-free WT virus at increasing concentrations of ACV, BVdU, and PFA. In addition to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21373931
DOI: 10.1007/s00430-011-0191-4

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