Article
Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction.
The Journal of general virology - 1 Mar 1991
Lacey S F, Suzutani T, Powell K L, Purifoy D J, Honess R W
Abstract excerpt
We have applied the polymerase chain reaction (PCR) technique to analyse mutations in the thymidine kinase (TK) gene of varicella-zoster virus (VZV) associated with resistance to the 5-bromovinyl (BVaraU) and 5-propynyl (PYaraU) analogues of arabinofuranosyl deoxyuridine. The results from this st...
Topics
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Arabinofuranosyluracil
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Herpesvirus 3, Human
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Thymidine Kinase
- Vero Cells