Sequence analysis of thymidine kinase-defective mutants of equine herpesvirus-1 (EHV-1).

doi:10.1016/0378-1119(93)90376-e

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Article

Sequence analysis of thymidine kinase-defective mutants of equine herpesvirus-1 (EHV-1).

Gene - 30 Apr 1993

Corrochano L M, Madueño F, Field H J, de la Fuente R

Abstract excerpt

We have amplified, cloned and sequenced the gene encoding the thymidine kinase (TK) of a wild-type strain (Ab4) of equine herpesvirus-1 (EHV-1) and two mutants with defective TK activity isolated for resistance to penciclovir (PCV). One of the mutants, PR1, has suffered a 879-bp deletion which reduces the size of TK to 180 bp. The other mutant, PR3, has an adenine to cytosine mutation resulting in a Lys38-->Thr...

Topics

Amino Acid Sequence
Base Sequence
DNA, Viral
Defective Viruses
Herpesvirus 1, Equid
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sequence Deletion
Thymidine Kinase
Viral Vaccines

Source

Open in PubMed

Identifiers

PMID: 8387060
DOI: 10.1016/0378-1119(93)90376-e

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