Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fluoroquinolone resistance associated with specific gyrase mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis.

The Journal of infectious diseases - 1 Nov 1996

Xu C, Kreiswirth B N, Sreevatsan S, Musser J M, Drlica K

Abstract excerpt

Fluoroquinolones are potent antibacterial agents being used clinically against multidrug-resistant tuberculosis. Treatment failure is thought to arise from acquisition of fluoroquinolone resistance by Mycobacterium tuberculosis. A collection of 13 resistant clinical isolates of M. tuberculosis was examined for ciprofloxacin sensitivity relative to controls exhibiting the same IS6110 DNA type. Specific alleles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Ciprofloxacin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type II

Share to Drug Resistance, Multiple

Share to Mutation

Share to Mycobacterium tuberculosis

Source

Identifiers

PMID: 8896523
DOI: 10.1093/infdis/174.5.1127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Fluoroquinolone resistance associated with specific gyrase mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis.PMID 8896523Read ↗

High Proportion of Fluoroquinolone-Resistant Mycobacterium tuberculosis Isolates with Novel Gyrase Polymorphisms and a <i>gyrA</i> Region Associated with Fluoroquinolone SusceptibilitySemantic proximity Read ↗

Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients.Semantic proximity Read ↗

Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.Semantic proximity Read ↗

New insights into fluoroquinolone resistance in Mycobacterium tuberculosis: functional genetic analysis of gyrA and gyrB mutations.Semantic proximity Read ↗

A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus.Semantic proximity Read ↗

In vitro-selected resistance to fluoroquinolones in two Brucella strains associated with mutational changes in gyrA.Semantic proximity Read ↗

Identification of novel resistance-associated mutations and discrimination within whole-genome sequences of fluoroquinolone-resistant Mycobacterium tuberculosis isolates.Semantic proximity Read ↗

Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.