Article
The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.
Human molecular genetics - 1 Apr 1995
Sobell J L, Lind T J, Sigurdson D C, Zald D H, Snitz B E, Grove W M, Heston L L, Sommer S S
Abstract excerpt
To determine whether mutations in the D5 dopamine receptor gene (DRD5) are associated with schizophrenia, the gene was examined in 78 unrelated schizophrenic individuals (156 DRD5 alleles). After amplification by the polymerase chain reaction, products were examined by dideoxy fingerprinting (ddF), a screening method related to single strand conformational polymorphism analysis that detects essentially 100% of...
Topics
- Adult
- Alleles
- Base Sequence
- DNA Mutational Analysis
- DNA Primers
- Female
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation