Article
Toward fully automated genotyping: allele assignment, pedigree construction, phase determination, and recombination detection in Duchenne muscular dystrophy.
American journal of human genetics - 1 Oct 1994
Perlin M W, Burks M B, Hoop R C, Hoffman E P
Abstract excerpt
Human genetic maps have made quantum leaps in the past few years, because of the characterization of > 2,000 CA dinucleotide repeat loci: these PCR-based markers offer extraordinarily high PIC, and within the next year their density is expected to reach intervals of a few centimorgans per marker....
Topics
- Alleles
- Automation
- Female
- Genetic Carrier Screening
- Genetic Techniques
- Humans
- Male
- Mathematics
- Models, Genetic
- Muscular Dystrophies
- Pedigree
- Phenotype
- Polymerase Chain Reaction
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid