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Article

Normalization of mineral homeostasis after reversal of osteopetrosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 1995

Nesbitt T, Marks S C, Jackson M E, Mackay C A, Drezner M K

Abstract excerpt

Whether a radiographic and histologic cure of osteopetrosis includes normalization of mineral homeostasis remains unknown. Thus, we explored the extent of defective mineral metabolism in the microphthalmic (mi/mi) mouse before and after cure. Under basal conditions mi mutants exhibit normocalcemia, hypophosphatemia, and elevated renal 25-hydroxyvitamin D-1-hydroxylase activity. However, administration of PTHrP (3...

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Source

Identifiers

PMID: 7484288
DOI: 10.1002/jbmr.5650100717

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Normalization of mineral homeostasis after reversal of osteopetrosis.PMID 7484288Read ↗

Neonatal reductions in osteoclast number and function account for the transient nature of osteopetrosis in the rat mutation microphthalmia blanc (mib).Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

Abnormal modulation of serum osteocalcin by dietary phosphate and 1,25-dihydroxyvitamin D3 in the hypophosphatemic mouse.Semantic proximity Read ↗

Bone metabolism in the osteopetrotic rat mutation microphthalmia blanc.Semantic proximity Read ↗

Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets.Semantic proximity Read ↗

Interdependence of skeletal sclerosis and elevated circulating levels of 1,25-dihydroxyvitamin D in osteopetrotic (op and tl) rats.Semantic proximity Read ↗

Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia.Semantic proximity Read ↗

Early lethality in Hyp mice with targeted deletion of Pth gene.Semantic proximity Read ↗

Abnormalities in bone cell function and endochondral ossification in the osteopetrotic toothless rat.Semantic proximity Read ↗

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Lack of evidence for rickets in the osteopetrotic rat mutation, toothless.Semantic proximity Read ↗

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