Article
Neonatal reductions in osteoclast number and function account for the transient nature of osteopetrosis in the rat mutation microphthalmia blanc (mib).
Bone - 1 Jan 2000
Cielinski M J, Marks S C
Abstract excerpt
We have examined the general and skeletal manifestations of osteopetrosis in a new, mild osteopetrotic mutation in the rat, microphalmia blanc (mib). Newborn mutant (mib) rats exhibit the typical skeletal deformities and sclerosis of osteopetrosis at birth, which are reduced significantly during...
Topics
- Aging
- Animals
- Animals, Newborn
- Body Weight
- Bone Resorption
- Bone and Bones
- Calcium
- Cell Count
- Dihydroxycholecalciferols
- Female
- Gene Expression Regulation
- Male
- Microphthalmos
- Microscopy, Electron, Scanning
- Mutation
- Osteoclasts
- Osteopetrosis
- Phosphorus