Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuated virulence of chitin-deficient mutants of Candida albicans.

Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 1995

Bulawa C E, Miller D W, Henry L K, Becker J M

Abstract excerpt

We have analyzed the role of chitin, a cell-wall polysaccharide, in the virulence of Candida albicans. Mutants with a 5-fold reduction in chitin were obtained in two ways: (i) by selecting mutants resistant to Calcofluor, a fluorescent dye that binds to chitin and inhibits growth, and (ii) by disrupting CHS3, the C. albicans homolog of CSD2/CAL1/DIT101/KT12, a Saccharomyces cerevisiae gene required for synthesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Fungal Proteins
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to Molecular Sequence Data

Share to Mutation

Share to Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 7479842
DOI: 10.1073/pnas.92.23.10570
PMCID: PMC40653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuated virulence of chitin-deficient mutants of Candida albicans.PMID 7479842Read ↗

Loss of CHT3 in Candida albicans wild-type strains increases surface-exposed chitin and affects host-pathogen interactionSemantic proximity Read ↗

Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence.Semantic proximity Read ↗

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.Semantic proximity Read ↗

Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity.Semantic proximity Read ↗

The Candida albicans CHS4 gene complements a Saccharomyces cerevisiae skt5/chs4 mutation and is involved in chitin biosynthesis.Semantic proximity Read ↗

Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans.Semantic proximity Read ↗

Chitosan biosynthesis and virulence in the human fungal pathogen <i>Cryptococcus gattii</i>Semantic proximity Read ↗

Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective Candida-innate immune interaction.Semantic proximity Read ↗

A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans.Semantic proximity Read ↗

The chsD and chsE genes of Aspergillus nidulans and their roles in chitin synthesis.Semantic proximity Read ↗

Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models.Semantic proximity Read ↗

DIT101 (CSD2, CAL1), a cell cycle-regulated yeast gene required for synthesis of chitin in cell walls and chitosan in spore walls.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.