Article
Attenuated virulence of chitin-deficient mutants of Candida albicans.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 1995
Bulawa C E, Miller D W, Henry L K, Becker J M
Abstract excerpt
We have analyzed the role of chitin, a cell-wall polysaccharide, in the virulence of Candida albicans. Mutants with a 5-fold reduction in chitin were obtained in two ways: (i) by selecting mutants resistant to Calcofluor, a fluorescent dye that binds to chitin and inhibits growth, and (ii) by dis...
Topics
- Animals
- Base Sequence
- Benzenesulfonates
- Candida albicans
- Chitin
- Chitin Synthase
- Drug Resistance, Microbial
- Fungal Proteins
- Genotype
- Heterozygote
- Homozygote
- Kidney
- Male
- Mice
- Mice, Inbred ICR
- Molecular Sequence Data
- Mutation
- Restriction Mapping