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Article

A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994

Gow N A, Robbins P W, Lester J W, Brown A J, Fonzi W A, Chapman T, Kinsman O S

Abstract excerpt

In the dimorphic fungus Candida albicans, the CHS2 gene encodes a chitin synthase that is expressed preferentially in the hyphal form. Gene disruption of CHS2 in this diploid asexual fungus was achieved by the "ura-blaster" protocol described for Saccharomyces [Alani, E., Cao, L. & Kleckner, N. (1987) Genetics 116, 541-545]. This involves the sequential disruption of multiple alleles by integrative transformation...

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Identifiers

PMID: 8016141
DOI: 10.1073/pnas.91.13.6216
PMCID: PMC44169

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A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans.PMID 8016141Read ↗

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The chsB gene of Aspergillus nidulans is necessary for normal hyphal growth and development.Semantic proximity Read ↗

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