Article
A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994
Gow N A, Robbins P W, Lester J W, Brown A J, Fonzi W A, Chapman T, Kinsman O S
Abstract excerpt
In the dimorphic fungus Candida albicans, the CHS2 gene encodes a chitin synthase that is expressed preferentially in the hyphal form. Gene disruption of CHS2 in this diploid asexual fungus was achieved by the "ura-blaster" protocol described for Saccharomyces [Alani, E., Cao, L. & Kleckner, N. (...
Topics
- Animals
- Candida albicans
- Candidiasis
- Cell Division
- Chitin
- Chitin Synthase
- Cyclophosphamide
- DNA, Fungal
- Female
- Genes, Fungal
- Genotype
- Immunosuppression Therapy
- Kidney
- Mice
- Mutagenesis, Insertional