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Article

Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models.

The Journal of infectious diseases - 1 Jul 2009

Chamilos Georgios, Nobile Clarissa J, Bruno Vincent M, Lewis Russell E, Mitchell Aaron P, Kontoyiannis Dimitrios P

Abstract excerpt

Candida albicans is the most common human fungal pathogen, yet the pathogenesis of C. albicans infection remains incompletely understood. We hypothesized that C. albicans has developed evolutionarily conserved mechanisms to invade disparate hosts and tested whether Toll mutant flies could serve as a model host for high-throughput screening of C. albicans virulence genes. We screened 34 C. albicans mutants...

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Identifiers

PMID: 19463063
DOI: 10.1086/599363
PMCID: PMC4449728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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