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Loss of CHT3 in Candida albicans wild-type strains increases surface-exposed chitin and affects host-pathogen interaction

5 Sept 2025

Abstract excerpt

The chitinase Cht3 plays a major role in the chitinolytic activity of the pathogenic yeast Candida albicans and has also been proposed as a major antigen with potential for vaccine development against systemic candidiasis. The current study aims to enhance our knowledge on the role of Cht3 in cell surface organization and virulence of C. albicans. To this end, CHT3 deletion mutants generated in two wild-type...

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PMID: 40980016
DOI: 10.3389/fcimb.2025.1654710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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