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Article

Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans.

Eukaryotic cell - 1 Sept 2011

Baker Lorina G, Specht Charles A, Lodge Jennifer K

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21784998
DOI: 10.1128/EC.05138-11
PMCID: PMC3187048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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