Accessibility of microRNA binding sites in metastable RNA secondary structures in the presence of SNPs.

doi:10.1093/bioinformatics/btt695

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Accessibility of microRNA binding sites in metastable RNA secondary structures in the presence of SNPs.

Bioinformatics (Oxford, England) - 1 Feb 2014

Day Luke, Abdelhadi Ep Souki Ouala, Albrecht Andreas A, Steinhöfel Kathleen

Abstract excerpt

MOTIVATION: We study microRNA (miRNA) bindings to metastable RNA secondary structures close to minimum free energy conformations in the context of single nucleotide polymorphisms (SNPs) and messenger RNA (mRNA) concentration levels, i.e. whether features of miRNA bindings to metastable conformations could provide additional information supporting the differences in expression levels of the two sequences defined...

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