Article
Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours.
Oncogene - 1 Sept 1991
Wright P A, Lemoine N R, Goretzki P E, Wyllie F S, Bond J, Hughes C, Röher H D, Williams E D, Wynford-Thomas D
Abstract excerpt
The p53 gene has been implicated as a tumour suppressor, with mutations occurring in many carcinomas, such as colon, breast and lung. We have sequenced exons 5, 7 and 8 containing conserved gene regions in the only available differentiated thyroid follicular carcinoma cell line and found a mutation at position 273, Arg----His, with no normal allele present. The same mutation was also present in DNA from the...
Topics
- Antibodies, Monoclonal
- Base Sequence
- Blotting, Southern
- Carcinoma
- Carcinoma, Papillary
- Cell Differentiation
- Cell Line
- DNA, Neoplasm
- Exons
- Genes, p53
- Homozygote