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Article

Low frequency of p53 mutations in human thyroid tumours; p53 and Ras mutation in two out of fifty-six thyroid tumours.

European journal of endocrinology - 1 Feb 1996

Salvatore D, Celetti A, Fabien N, Paulin C, Martelli M L, Battaglia C, Califano D, Monaco C, Viglietto G, Santoro M, Fusco A

Abstract excerpt

OBJECTIVE: p53 is a well-known nuclear phosphoprotein encoded by a suppressor gene know to be mutated in various kinds of human tumours. A relationship between p53 gene mutation and tumour progression seems to be a common feature of several neoplasias. DESIGN: In order to investigate the role of p53 mutations in human thyroid tumours, DNA samples derived from fifty-six neoplastic tissues, ranging from benign...

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Identifiers

PMID: 8630516
DOI: 10.1530/eje.0.1340177

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Low frequency of p53 mutations in human thyroid tumours; p53 and Ras mutation in two out of fifty-six thyroid tumours.PMID 8630516Read ↗

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