Article
Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells.
Oncogene - 16 Nov 1995
Tamura T, Aoyama N, Saya H, Haga H, Futami S, Miyamoto M, Koh T, Ariyasu T, Tachi M, Kasuga M
Abstract excerpt
To investigate the biological function of p53 in colon carcinoma cells, a wild-type p53 expression plasmid under the control of the human cytomegalovirus promoter was stably transfected into the human colon adenocarcinoma cell line WiDr, which carries a mutation of the p53 gene at codon 273. Exogenous wild-type p53 transcripts were detected at various expression levels in 8 of 117 G418-resistant clones. The...
Topics
- Adenocarcinoma
- Antibodies
- Apoptosis
- Base Sequence
- Colonic Neoplasms
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Fas Ligand Protein
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans