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Article

Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29.

Cell biology international - 1 Mar 2008

Zang Fenglin, Sun Baocun, Zhao Xiulan, Niu Ruifang, Zhang Shiwu, Yu Man, Wei Xiyin, Zhang Lin

Abstract excerpt

The cellular Fas-associated death domain-like interleukin-1beta-converting enzyme inhibitory protein-long form (c-FLIP(L)) is a key regulator of Fas signaling, although owing a dominant-negative homologue of caspase-8, the role of c-FLIP(L) remains controversial. In the present study, two pairs of small interfering RNA (siRNA) directed against c-FLIP(L) were used to assess the effect of c-FLIP(L) on Fas-mediated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18243739
DOI: 10.1016/j.cellbi.2007.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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