Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor.

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Article

Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor.

Molecular pharmacology - 1 Oct 1995

Chung F Z, Wu L H, Tian Y, Vartanian M A, Lee H, Bikker J, Humblet C, Pritchard M C, Raphy J, Suman-Chauhan N

Abstract excerpt

Two classes of structurally different tachykinin neurokinin3 (NK3) antagonists were used to evaluate species difference in antagonist binding between human and rat NK3 receptors. In competition binding experiments with [125I-MePhe7]NKB as radioligand, PD 154740, PD 157672, SR 48968, and SR 142801 displayed lower Ki values for the human NK3 receptor (40 +/- 4, 12 +/- 1,350 +/- 50, and 0.40 +/- 0.05 nM,...

Topics

Animals
Benzamides
Binding, Competitive
CHO Cells
Cricetinae
Dipeptides
Humans
Inositol Phosphates
Iodine Radioisotopes
Kinetics
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurokinin B

Phenylalanine

Piperidines

Radioligand Assay

Rats

Receptors, Neurokinin-3

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 7476898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7476898-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor.PMID 7476898Read ↗

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