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Article

Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants.

Biochemical pharmacology - 15 Aug 2008

Ahlstedt Ingela, Engberg Susanna, Smith John, Perrey Chris, Moody Adrian, Morten John, Lagerström-Fermér Maria, Drmota Tomas, von Mentzer Bengt, Påhlman Ingrid, Lindström Erik

Abstract excerpt

Tachykinin NK(2) receptor antagonists are potentially beneficial in treating various disorders including irritable bowel syndrome, urinary incontinence, depression and anxiety. The current study evaluates the frequency of single nucleotide polymorphisms (SNPs) in the human NK(2) receptor gene (TACR2). In addition, the potency of the endogenous peptide agonist neurokinin A (NKA), and the small molecule antagonists...

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Source

Identifiers

PMID: 18601911
DOI: 10.1016/j.bcp.2008.06.003

Genes

TACR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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