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Article

SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity.

Microbiology (Reading, England) - 1 Jul 1998

Benjelloun-Touimi Zineb, Si Tahar Mustapha, Montecucco Cesare, Sansonetti Philippe J, Parsot Claude

Abstract excerpt

Shigellosis is characterized by a strong inflammatory response which is induced by bacteria invading the colonic mucosa. Characterization of a sepA mutant indicated that SepA, the major protein secreted by Shigella flexneri growing in laboratory media, might be involved in invasion and destruction of the host intestinal epithelium. The sequence of the first 500 residues of mature SepA (110 kDa) is homologous to...

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PMID: 9695914
DOI: 10.1099/00221287-144-7-1815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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