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Article

Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammals.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2007

Popadin Konstantin, Polishchuk Leonard V, Mamirova Leila, Knorre Dmitry, Gunbin Konstantin

Abstract excerpt

After the effective size of a population, N(e), declines, some slightly deleterious amino acid replacements which were initially suppressed by purifying selection become effectively neutral and can reach fixation. Here we investigate this phenomenon for a set of all 13 mitochondrial protein-coding genes from 110 mammalian species. By using body mass as a proxy for N(e), we show that large mammals (i.e., those...

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Identifiers

PMID: 17679693
DOI: 10.1073/pnas.0701256104
PMCID: PMC1948928

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