From Drift to Draft: How Much Do Beneficial Mutations Actually Contribute to Predictions of Ohta's Slightly Deleterious Model of Molecular Evolution?

doi:10.1534/genetics.119.302869

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Article

From Drift to Draft: How Much Do Beneficial Mutations Actually Contribute to Predictions of Ohta's Slightly Deleterious Model of Molecular Evolution?

Genetics - 1 Apr 2020

Chen Jun, Glémin Sylvain, Lascoux Martin

Abstract excerpt

Since its inception in 1973, the slightly deleterious model of molecular evolution, also known as the nearly neutral theory of molecular evolution, remains a central model to explain the main patterns of DNA polymorphism in natural populations. This is not to say that the quantitative fit to data are perfect. A recent study used polymorphism data from Drosophila melanogaster to test whether, as predicted by the...

Topics

Animals
Drosophila melanogaster
Evolution, Molecular
Genetic Drift
Genetic Fitness
Genetic Linkage
Genome, Insect
Genome, Plant
Models, Genetic
Mutation
Selection, Genetic

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Identifiers

PMID: 32015019
DOI: 10.1534/genetics.119.302869
PMCID: PMC7153929

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