Article
Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer - 1 Jan 1995
Cristaudo A, Vivaldi A, Sensales G, Guglielmi G, Ciancia E, Elisei R, Ottenga F
Abstract excerpt
The ras gene is one of the oncogenes most commonly detected in human cancers; this protooncogene is converted to active oncogene by point mutations occurring at either codon 12, 13, or 61. SV40 is a DNA-transforming simian virus, a 105 bp sequence of which has been shown recently to be present in a significant fraction of human mesothelioma cells. Eleven human malignant mesotheliomas were examined for H-ras gene...
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