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Article

Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.

Oncogene - 20 Jun 2002

Toyooka Shinichi, Carbone Michele, Toyooka Kiyomi O, Bocchetta Maurizio, Shivapurkar Narayan, Minna John D, Gazdar Adi F

Abstract excerpt

Mesotheliomas are tumors arising from mesothelial cells and are associated with asbestos exposure and approximately 50% contain simian virus 40 (SV40) DNA sequences. SV40 infection of human mesothelial cells (HM) causes early cellular immortalization and late transformation. Aberrant methylation is a major mech-anism for loss of function of tumor suppressor genes (TSGs). We recently reported that of seven genes...

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PMID: 12082623
DOI: 10.1038/sj.onc.1205381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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