Article
Acetylation and its role in the mutagenicity of the antihypertensive agent hydralazine.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 1995
Lemke L E, McQueen C A
Abstract excerpt
1-Hydrazinophthalazine [hydralazine (HDZ)] is a hydrazine derivative that is a direct acting vasodilator effective in the treatment of essential hypertension. HDZ is biotransformed by the phase II conjugation enzyme N-acetyltransferase (NAT) forming acetyl HDZ, which spontaneously cyclized to the...
Topics
- Acetylation
- Animals
- Antihypertensive Agents
- Arylamine N-Acetyltransferase
- Biotransformation
- Codon
- Hydralazine
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL
- Mutagenicity Tests
- Mutagens