Acetylator phenotype and lupus erythematosus.

Abstract excerpt

There are several known therapeutic implications of acetylator phenotype; among them, the association of a higher incidence of procainamide- and hydralazine-induced lupus in slow acetylators. Presumably, this is because acetylation of the aromatic amine or hydrazine functional group leads to a non-toxic product. Several other drugs which have been implicated in drug-induced lupus also contain an aromatic amine or...

Topics

• Acetylation
• Acetyltransferases
• Humans
• Hydralazine
• Lupus Erythematosus, Systemic
• Phenotype
• Procainamide