Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens.

Article

Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens.

Cancer research - 1 Dec 1992

Palmer L A, Hukku B, Harmon J M

Abstract excerpt

The sensitivity of the human glucocorticoid receptor (hGR) gene to mutagenesis by the cancer chemotherapeutic drugs adriamycin, bleomycin, and chlorambucil was evaluated using glucocorticoid-sensitive (dexs) subclones of the human leukemic cell line CEM-C7. Treatment of cells with either bleomyci...

Topics

Alleles
Bleomycin
Cells, Cultured
Chlorambucil
Chromosomes, Human, Pair 5
Dexamethasone
Doxorubicin
Gene Deletion
Humans
Karyotyping
Phenotype
RNA, Messenger
Receptors, Glucocorticoid

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