Article
Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1997
de Lange P, Koper J W, Huizenga N A, Brinkmann A O, de Jong F H, Karl M, Chrousos G P, Lamberts S W
Abstract excerpt
The molecular mechanisms underlying primary glucocorticoid resistance or hypersensitivity are not well understood. Using transfected COS-1 cells as a model system, we studied gene regulation by naturally occurring mutants of the glucocorticoid receptor (GR) with single-point mutations in the regions encoding the ligand-binding domain or the N-terminal domain reflecting different phenotypic expression. We analyzed...
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