Article
Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1997
de Lange P, Koper J W, Huizenga N A, Brinkmann A O, de Jong F H, Karl M, Chrousos G P, Lamberts S W
Abstract excerpt
The molecular mechanisms underlying primary glucocorticoid resistance or hypersensitivity are not well understood. Using transfected COS-1 cells as a model system, we studied gene regulation by naturally occurring mutants of the glucocorticoid receptor (GR) with single-point mutations in the regi...
Topics
- Animals
- COS Cells
- Collagenases
- Dexamethasone
- Genetic Variation
- Humans
- Intercellular Adhesion Molecule-1
- Luciferases
- Mammary Tumor Virus, Mouse
- Mutation
- NF-kappa B
- Prolactin
- Promoter Regions, Genetic
- Receptors, Glucocorticoid
- Recombinant Proteins