Article
Changes in acetylator phenotype over the lifespan in the Wistar rat.
Mechanisms of ageing and development - 1 Jan 2006
Lares-Asseff Ismael, Camacho Guadalupe A, Guillé Adrián J, Toledo Alejandra R, Trujillo Francisca, Reyes Rosa E, Juárez Hugo M, Pérez Gabriela
Abstract excerpt
UNLABELLED: Acetylation capacity during drug metabolism differs between species, gender and age groups. OBJECTIVE: The purpose of this work was to determine variations in the acetylating phenotype (AP), in a longitudinal study, as a function of growth and development. METHODS: Twenty male Wistar rats were studied. AP was determined on days 21, 48, 114, 180, 457 and 780 with oral doses of 30mg/kg of sulphadiazine...
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