Article
Metabolic oxidation phenotypes as markers for susceptibility to lung cancer.
Nature - 1 Jan 2000
Ayesh R, Idle J R, Ritchie J C, Crothers M J, Hetzel M R
Abstract excerpt
That bronchial carcinoma is not an inevitable consequence of cigarette smoking has stimulated the search for host factors that might influence the susceptibility of the individual smoker. One plausible host factor would be a polymorphic gene controlling the metabolic oxidative activation of chemical carcinogens, giving rise to wide inter-subject variation in the generation of cancer-inducing and/or promoting...
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