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Article

A metric model of amino acid substitution.

Bioinformatics (Oxford, England) - 22 May 2004

Xu Weijia, Miranker Daniel P

Abstract excerpt

MOTIVATION: We address the question of whether there exists an effective evolutionary model of amino-acid substitution that forms a metric-distance function. There is always a trade-off between speed and sensitivity among competing computational methods of determining sequence homology. A metric model of evolution is a prerequisite for the development of an entire class of fast sequence analysis algorithms that...

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PMID: 14871874
DOI: 10.1093/bioinformatics/bth065

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PAM

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