Article
A combined empirical and mechanistic codon model.
Molecular biology and evolution - 1 Feb 2007
Doron-Faigenboim Adi, Pupko Tal
Abstract excerpt
The evolutionary selection forces acting on a protein are commonly inferred using evolutionary codon models by contrasting the rate of synonymous to nonsynonymous substitutions. Most widely used models are based on theoretical assumptions and ignore the empirical observation that distinct amino acids differ in their replacement rates. In this paper, we develop a general method that allows assimilation of...
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