[Allelic exclusion in hybridomas. I. Isolation and properties of a hybrid clone producing two allelic variants of light chain immunoglobulins in the rat].

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Article

[Allelic exclusion in hybridomas. I. Isolation and properties of a hybrid clone producing two allelic variants of light chain immunoglobulins in the rat].

Molekuliarnaia biologiia - 1 Jan 2000

Cherepakhin V V, Petrosian M N, Ibragimov A R, Bogacheva G T, Trakht I N

Abstract excerpt

Expression of RI-1a and RI-1b allelic genes controlling the production of rat lg kappa L-chains by hybridoma cells in vitro was studied. By fusing mouse myeloma cells with RI-1a/RI-1b heterozygous rat splenocytes the unique cloned hybrid cell line secreting both allelic variants has been establis...

Topics

Alleles
Animals
Cloning, Molecular
Gene Expression Regulation
Hybridomas
Immunoglobulin Light Chains
Immunoglobulin kappa-Chains
Mice
Multiple Myeloma
Phenotype
Rats
Spleen

Source

Open in PubMed

Identifiers

PMID: 6425644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6425644-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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