Chance, necessity and antibody gene dynamics.

doi:10.1038/303023a0

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Article

Chance, necessity and antibody gene dynamics.

Nature - 1 Jan 2000

Coleclough C

Abstract excerpt

Early in their development B lymphocytes commit themselves to the expression of only one immunoglobulin light-chain gene and only one heavy-chain gene out of the large numbers of available loci. Here I shall present the view that the initial selection of loci for expression is made by chance, whe...

Topics

Alleles
Animals
Antibody Diversity
B-Lymphocytes
Cell Differentiation
Gene Expression Regulation
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains
Immunoglobulins
T-Lymphocytes

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