Article
Oxidation phenotyping in alcoholics with liver disease of varying severity.
Alcoholism, clinical and experimental research - 1 Jan 2000
Lanthier P L, Reshef R, Shah R R, Oates N S, Smith R L, Morgan M Y
Abstract excerpt
The propensity to develop alcoholic cirrhosis is probably, at least in part, genetically determined. A striking similarity exists histologically between perhexiline and alcohol-related hepatitis and both are potentially precirrhotic lesions. Liver damage due to perhexiline is associated with impaired drug oxidation capacity which is genetically determined and tested by use of debrisoquine. Oxidation phenotyping...
Topics
- Adult
- Aged
- Alcohol Drinking
- Alcoholism
- Animals
- Biotransformation
- Chick Embryo
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Dogs
- Fatty Liver, Alcoholic
- Female